Related Experiment Video

Updated: Sep 9, 2025

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.1K

[Disseminated intravascular coagulation associated with vascular abnormalities]

Shinya Yamada1, Hidesaku Asakura1

  • 1Department of Hematology, Kanazawa University Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|September 3, 2025
PubMed

Insights

Disseminated intravascular coagulation (DIC) linked to vascular abnormalities requires specific diagnosis using coagulation and fibrinolysis markers. Treatment focuses on the underlying cause, anticoagulation, or combined therapies, guided by patient condition and continuous testing.

Area of Science:

  • Hematology
  • Vascular Medicine
  • Critical Care Medicine

Background:

  • Disseminated intravascular coagulation (DIC) frequently complicates vascular abnormalities, including aortic aneurysms, dissections, vasculitis, and malformations.
  • DIC associated with vascular abnormalities often presents with enhanced fibrinolysis, necessitating specialized diagnostic and therapeutic approaches.

Purpose of the Study:

  • To outline diagnostic findings and treatment strategies for DIC in the context of vascular abnormalities.
  • To provide guidance based on the "Clinical practice guidelines for management of disseminated intravascular coagulation (DIC) in Japan 2024".

Main Methods:

  • Review of diagnostic markers for coagulation activation (e.g., thrombin-antithrombin complexes) and fibrinolysis activation (e.g., plasmin-α2 plasmin inhibitor complex).
  • Analysis of treatment options including addressing underlying diseases, anticoagulant therapy, combined anticoagulant and antifibrinolytic therapy, and Factor XIII concentrate use.

Main Results:

  • Diagnostic criteria emphasize specific coagulation and fibrinolysis activation markers.
  • Treatment strategies are tailored based on bleeding symptoms, test results, underlying conditions, and patient status, with options ranging from observation to aggressive combination therapies.

Conclusions:

  • Effective management of DIC with vascular abnormalities hinges on accurate diagnosis using activation markers and individualized treatment plans.
  • Continuous monitoring, expert collaboration, and a robust testing system are essential for optimizing patient outcomes.

Keywords:
Disseminated intravascular coagulationEnhanced-fibrinolytic-type DICVascular abnormalities

More Related Videos

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.1K
Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models04:40

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

2.6K

Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.2K
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
40
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
889
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
22
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
9.2K
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
34