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Updated: Sep 9, 2025

Intravenous Injections in Neonatal Mice
Published on: November 11, 2014
Physiology-guided vasoactive therapy in neonates: rethinking dopamine as first-line
Audrey Hébert1, Satyan Lakshminrusimha2, Danielle R Rios3
1Division of Neonatology, Department of Pediatrics, CHU de Québec, Laval University, Québec, QC, Canada. audrey.hebert.2@ulaval.ca.
Abstract:
Dopamine has been widely used as a first-line cardiovascular agent in neonatal intensive care units (NICUs) for the management of hypotension and circulatory support. While its effectiveness in increasing blood pressure is established, its potential effects on pulmonary vascular resistance, myocardial function, and overall hemodynamics require further consideration. This review explores the role of dopamine in neonatal hemodynamic management and considers alternative vasoactive agents tailored to specific pathophysiological conditions. A more individualized, physiology-based approach to cardiovascular support in neonates may help optimize treatment strategies.
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