Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

58.5K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
58.5K
Neurulation01:30

Neurulation

42.6K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.6K
Cleavage and Blastulation01:33

Cleavage and Blastulation

45.7K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
45.7K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

2.7K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
2.7K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

2.4K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.4K
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

2.5K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Event-based spatiotemporal networks for modelling emergent phenomena in complex systems.

Nature communications·2026
Same author

Nucleoli-localized KANSL2 as an epigenetic regulator of ribosome biogenesis in glioblastoma cells.

Communications biology·2026
Same author

Anisotropic stretch biases the self-organization of actin fibers in multicellular Hydra aggregates.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

A genome resource for the marine annelid Platynereis spp.

BMC genomics·2025
Same author

Timely neurogenesis drives the transition from nematic to crystalline nuclear packing during retinal morphogenesis.

Science advances·2025
Same author

Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.

BMC biology·2024
Same journal

Retraction Note: NSD2 targeting reverses plasticity and drug resistance in prostate cancer.

Nature·2026
Same journal

Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies.

Nature·2026
Same journal

Vaccination elicits HIV broadly neutralizing antibodies in primates.

Nature·2026
Same journal

Child online safety needs more than social-media bans.

Nature·2026
Same journal

Ebola preparedness must start with ecosystems and before humans show symptoms.

Nature·2026
Same journal

AI tools can speed up thinking, but evidence still comes from the lab bench.

Nature·2026
See all related articles

Related Experiment Video

Updated: Sep 9, 2025

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis
09:52

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

Published on: March 12, 2014

12.0K

Patterned invagination prevents mechanical instability during gastrulation.

Bruno C Vellutini1, Marina B Cuenca2, Abhijeet Krishna2,3,4

  • 1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. vellutini@mpi-cbg.de.

Nature
|September 3, 2025
PubMed
Summary
This summary is machine-generated.

The cephalic furrow in fly embryos counteracts mechanical stress during gastrulation. This structure may have evolved to stabilize development against mechanical challenges, offering insights into morphogenetic evolution.

More Related Videos

Generation of Naïve Blastoderm Explants from Zebrafish Embryos
07:21

Generation of Naïve Blastoderm Explants from Zebrafish Embryos

Published on: July 30, 2021

3.5K
Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

9.5K

Related Experiment Videos

Last Updated: Sep 9, 2025

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis
09:52

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

Published on: March 12, 2014

12.0K
Generation of Naïve Blastoderm Explants from Zebrafish Embryos
07:21

Generation of Naïve Blastoderm Explants from Zebrafish Embryos

Published on: July 30, 2021

3.5K
Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

9.5K

Area of Science:

  • Developmental Biology
  • Evolutionary Biology
  • Biophysics

Background:

  • Mechanical forces are essential for embryonic development and morphogenesis.
  • The role of mechanical forces in the evolution of developmental processes is not well understood.

Purpose of the Study:

  • To investigate the mechanical role of the cephalic furrow, an evolutionary novelty in fly embryos, during Drosophila gastrulation.
  • To explore the evolutionary origins of the cephalic furrow in relation to mechanical challenges.

Main Methods:

  • In vivo experiments in Drosophila embryos.
  • In silico simulations of embryonic development.
  • Comparative genetic analysis of species with and without the cephalic furrow.

Main Results:

  • The cephalic furrow counteracts increased compressive stress at the head-trunk boundary during gastrulation.
  • This mechanical role prevents developmental instabilities.
  • Changes in buttonhead transcription factor expression correlate with the evolution of the cephalic furrow.

Conclusions:

  • The cephalic furrow may have evolved to stabilize morphogenesis against mechanical challenges during dipteran gastrulation.
  • Mechanical forces can drive the evolution of developmental innovations.
  • This study provides empirical evidence for the interplay between mechanics and developmental evolution.