Related Experiment Video

Updated: May 6, 2026

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients
05:01

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

Published on: October 17, 2017

7.1K

Intracranial pressure trajectories and functional outcomes in pediatric intracranial hemorrhage: a group-based

Lijuan Zhang1, Xiaomin Cui1, Ming Zhang1

  • 1Department of Surgical Intensive Care Unit, Children's Hospital of Nanjing Medical University, No.72 Guangzhou Road, Nanjing, 210008, Jiangsu Province, China.

European Journal of Pediatrics
|September 3, 2025
PubMed

Insights

Monitoring intracranial pressure (ICP) in pediatric patients with intracranial hemorrhage (ICH) is vital. This study identified distinct ICP trajectory patterns, revealing that certain dynamic ICP patterns are linked to poor neurologic outcomes.

Area of Science:

  • Pediatric Neurology
  • Neurocritical Care
  • Clinical Outcomes Research

Background:

  • Intracranial pressure (ICP) is critical for outcomes in pediatric intracranial hemorrhage (ICH).
  • Existing research primarily uses static ICP measurements, lacking insight into longitudinal patterns.

Purpose of the Study:

  • To identify distinct intracranial pressure (ICP) trajectory patterns in pediatric patients with intracranial hemorrhage (ICH).
  • To assess the impact of these ICP patterns on clinical outcomes.
  • To explore associations between ICP dynamics and six-month functional outcomes.

Main Methods:

  • Group-based trajectory modeling (GBTM) was used to analyze hourly ICP data from pediatric ICH patients over four days.
  • Short-term ICP fluctuations (ΔICP) were calculated to assess ICP dynamics.
  • Multivariable logistic regression analyzed associations between ICP trajectories and six-month outcomes.

Main Results:

  • Five distinct ICP trajectories were identified in 201 pediatric ICH patients.
  • Significant differences were observed in mechanical ventilation, vasoactive agent use, pupil reactivity, craniectomy, ICP values, ΔICP variability, GCS, and pGOSE scores across trajectories.
  • The 'High-Fluctuating' and 'Mid-Range Stable with Variability' ICP trajectory groups showed significantly higher odds of poor six-month outcomes.

Conclusions:

  • Substantial heterogeneity exists in ICP trajectories among children with ICH.
  • Three identified ICP trajectory patterns are significantly associated with poor neurologic outcomes.
  • Characterizing dynamic ICP subtypes can aid in early risk stratification and understanding ICP regulation.

Keywords:
Clinical outcomesGroup based trajectory modelingIntracranial hemorrhageIntracranial pressurePediatric

More Related Videos

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury06:18

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

Published on: March 26, 2019

9.1K
Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model08:18

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model

Published on: February 8, 2022

2.5K

Related Concept Videos

Pre-Procedural Guidelines for Assessing Blood Pressure01:10

Pre-Procedural Guidelines for Assessing Blood Pressure

Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
882
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
2.0K
Stress: General Loading Conditions01:15

Stress: General Loading Conditions

To grasp the intricacy of real-world conditions where multiple loads are applied simultaneously to a structure, one might visualize a section passing through a specific point within a body, aligned parallel to the xy plane. This section is subjected to various forces, including original loads, normal forces, and shearing forces.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes....
743
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
52