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Angina V: Nursing Management01:20

Angina V: Nursing Management

234
Angina, a symptom of myocardial ischemia, requires a structured nursing management approach to ensure effective care and prevent complications like myocardial infarction. Comprehensive nursing care involves assessing, diagnosing, planning, implementing interventions, and evaluating outcomes, all tailored to the individual patient's needs.Patient AssessmentNursing assessment begins with a detailed subjective evaluation of symptoms, which typically include chest pain or pressure radiating to the...
234
Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

152
Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
152
Angina I: Introduction01:30

Angina I: Introduction

396
Definition and Symptoms: Angina (angina pectoris) is chest pain or discomfort caused by myocardial ischemia, which occurs when the heart muscle receives insufficient oxygen-rich blood. It typically manifests as pressing, squeezing, or crushing sensations in the chest and may radiate to the shoulders, arms, neck, jaw, or back.Primary Cause: In a healthy state, the coronary arteries can dilate (widen) to increase blood flow and meet the increased oxygen demand during physical activity or...
396
Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

204
Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
204
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

219
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
219
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

661
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
661

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Related Experiment Video

Updated: Dec 24, 2025

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:23

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

144

Decoding monocyte signatures in ischemic stroke: A multi-scale transcriptomic approach.

Yanyi Peng1, Bo Xiao1,2, Mengqi Zhang1,2

  • 1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Neural Regeneration Research
|September 4, 2025
PubMed
Summary
This summary is machine-generated.

This study reveals key monocyte communication networks in ischemic stroke, identifying novel predictive genes and validating abhydrolase domain-containing protein 2

Keywords:
CellChatabhydrolase domain-containing protein 2bulk-RNA sequencingdiagnosis modelgene signatureischemic strokemonocytesphagocytosisreactive oxygen speciessingle-cell transcriptomics

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Last Updated: Dec 24, 2025

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Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
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Area of Science:

  • Neuroimmunology
  • Molecular Biology
  • Genomics

Background:

  • Monocytes are critical for post-stroke immune responses.
  • Understanding monocyte regulatory networks in ischemic stroke is limited, hindering targeted therapies.

Purpose of the Study:

  • To map monocyte communication networks in ischemic stroke.
  • To identify key genes and regulatory mechanisms for targeted immunomodulatory therapies.

Main Methods:

  • Multi-omics approach: single-cell and bulk transcriptomics.
  • Bioinformatic analyses: CellChat, Lasso regression, GSEA, mircode, RcisTarget.
  • Experimental validation: oxygen-glucose deprivation and transient middle cerebral artery occlusion models.

Main Results:

  • Identified elevated monocyte infiltration in stroke tissue.
  • Developed a seven-gene predictive model for ischemic stroke.
  • Validated the role of abhydrolase domain-containing protein 2 in enhancing monocyte function.

Conclusions:

  • This study elucidates post-stroke monocyte networks and identifies key regulatory genes.
  • Findings support the development of targeted immunotherapies and precision diagnostics for ischemic stroke.
  • Abhydrolase domain-containing protein 2 shows therapeutic potential in modulating monocyte activity.