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Published on: February 14, 2025
The Dark Side of NK Cells in Cancer Immunotherapy
Felipe Galvez-Cancino1, Maria Armero1, David R Withers2
1Laboratory of Immune-Regulation, Centre for Immuno-Oncology, Nuffield Department of Medicine, Oxford, United Kingdom.
None:
NK cells are a subset of innate lymphoid cells originally identified in mice and humans based on their ability to mediate cytotoxicity against transformed cells. However, two recent back-to-back studies in this issue of Cancer Discovery reveal that NK cell infiltration is not always beneficial; rather, it can impair the efficacy of immune checkpoint blockade through immune-regulatory mechanisms. See related article by Pozniak et al., p. 1819 See related article by Song et al., p. 1835.
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