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Thrombosis in Brothers With Protein S Deficiency: Case Series
Abate Bane Shewaye1,2, Seifu Kebede1, Amsalework Daniel1
1Department of Internal Medicine Adera Medical and Surgical Center Addis Ababa Ethiopia.
Clinical Case Reports
|September 4, 2025
Summary
Hereditary protein S deficiency, a rare cause of blood clots, raises venous thromboembolism risk. Early diagnosis and anticoagulation are key to preventing serious complications.
Area of Science:
- Hematology
- Genetics
- Vascular Medicine
Background:
- Hereditary protein S deficiency is a rare genetic disorder.
- It is a significant risk factor for venous thromboembolism (VTE).
- VTE can manifest in unusual locations, posing diagnostic challenges.
Purpose of the Study:
- To highlight the clinical significance of hereditary protein S deficiency.
- To emphasize the importance of early diagnosis and management strategies.
- To discuss the role of familial screening in at-risk populations.
Main Methods:
- Review of clinical cases and genetic data.
- Analysis of thrombotic events in patients with protein S deficiency.
- Evaluation of anticoagulation efficacy and safety.
Main Results:
- Confirmed association between hereditary protein S deficiency and increased VTE risk.
- Demonstrated occurrence of thrombosis in atypical sites.
- Highlighted the effectiveness of long-term anticoagulation in preventing recurrent events.
Conclusions:
- Hereditary protein S deficiency requires prompt identification and management.
- Familial screening is crucial for identifying at-risk relatives.
- Long-term anticoagulation is vital for mitigating VTE complications and improving patient prognosis.
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