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Updated: May 6, 2026

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
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Unexpected renal influence on isavuconazole trough concentrations: two case reports and literature review

Hui Li1, Xiaoshuang He1, Qiuya Lu2

  • 1Department of Pharmacy, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Frontiers in Medicine
|September 4, 2025
PubMed

Insights

Isavuconazole (ISA) monitoring is usually not needed for invasive aspergillosis. However, impaired kidney function may increase ISA levels, potentially causing adverse drug reactions, warranting further study.

Area of Science:

  • Pharmacology
  • Nephrology
  • Infectious Diseases

Background:

  • Isavuconazole (ISA) is a crucial antifungal agent for invasive aspergillosis.
  • Routine therapeutic drug monitoring (TDM) for ISA is generally not recommended.
  • Existing data suggest renal function does not significantly impact ISA pharmacokinetics.
Keywords:
adverse drug reactionsinvasive aspergillosisisavuconazolerenal functiontherapeutic drug monitoring

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