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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

740
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
740
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Related Experiment Video

Updated: Sep 9, 2025

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
07:13

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Optic Nerve Head Structural Changes After Intravitreal Injection.

Dania A Rahal1, Darrin A McFall1, Muhammad Z Chauhan1

  • 1Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Clinical Ophthalmology (Auckland, N.Z.)
|September 4, 2025
PubMed
Summary
This summary is machine-generated.

Intravitreal injections (IVIs) modestly increase optic nerve head (ONH) pit depth. Prior IVIs inversely correlated with this change, suggesting cumulative structural effects relevant to glaucoma progression.

Keywords:
depthinjectionsintravitrealoptic nervepit

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Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Glaucoma Research

Background:

  • Intravitreal injections (IVIs) are common treatments for retinal diseases.
  • The acute anatomical effects of IVIs on the optic nerve head (ONH) and Bruch's membrane opening (BMO) are not fully understood.
  • Understanding these changes is crucial given the ONH's role in glaucoma.

Purpose of the Study:

  • To evaluate acute anatomical changes in BMO and ONH pit depth following anti-VEGF IVIs.
  • To investigate factors influencing these anatomical changes, including prior injection history.

Main Methods:

  • Prospective study of 51 patients receiving anti-VEGF IVIs.
  • High-resolution spectral domain optical coherence tomography (OCT) imaging pre- and post-injection.
  • Measurement of ONH pit depth and BMO changes.

Main Results:

  • A statistically significant average increase in ONH pit depth of 31.57 ± 24.36 μm post-IVI (p < 0.001).
  • The number of previous IVIs showed a significant inverse correlation with the change in pit depth (r = -0.369, p = 0.004).
  • No significant associations found between other patient variables or IOP elevation and pit depth/BMO changes.

Conclusions:

  • Intravitreal injections are associated with a modest acute increase in ONH pit depth.
  • Repeated IVIs may have a cumulative effect on ONH structure.
  • These structural changes could be relevant to glaucomatous progression, warranting further investigation.