Related Experiment Video
Updated: Sep 9, 2025
05:49
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
Published on: November 29, 2024
717
Platelet Activation and a Platelet Biosignature Are Associated With Cardiovascular Risk in Patients With Controlled
Michael S Garshick1,2,3,4, Kamelia Drenkova2, Filipp Kazatsker2
1Department of Medicine, Center for the Prevention of Cardiovascular Disease, Brigham and Women's Hospital, Boston, MA (M.S.G., J.S.B.).
Arteriosclerosis, Thrombosis, and Vascular Biology
|September 4, 2025
Summary
Platelets are more active in psoriasis patients, showing altered gene expression linked to inflammation and clotting. This platelet profile predicts increased cardiovascular disease risk, highlighting a potential therapeutic target.
Area of Science:
- Cardiovascular Research
- Dermatology
- Immunology
- Genomics
Background:
- Atherosclerosis mechanisms and cardiovascular risk identification in psoriasis remain unclear.
- Increased platelet activity in psoriasis contributes to vascular dysfunction.
- Investigating platelet phenotype and transcriptome offers insight into psoriasis-related cardiovascular risk.
Purpose of the Study:
- To investigate platelet phenotype and transcriptome in psoriasis patients.
- To determine the association between platelet transcriptomic profiles and cardiovascular risk.
- To explore platelet-driven mechanisms contributing to cardiovascular disease in psoriasis.
Main Methods:
- Psoriasis patients and controls underwent platelet aggregation and activation studies.
- Platelet RNA sequencing was performed to generate a psoriasis platelet transcriptomic score.
- The score's correlation with arterial stiffness, coronary calcium, and incident myocardial infarction was assessed.
Main Results:
- Psoriasis patients exhibited higher platelet aggregation and increased leukocyte-, neutrophil-, and lymphocyte-platelet aggregates.
- Platelet RNA sequencing revealed distinct gene expression patterns in psoriasis, associated with inflammation and clotting pathways.
- The psoriasis platelet transcriptomic score correlated with arterial stiffness, coronary calcium, and predicted myocardial infarction in high-risk individuals.
Conclusions:
- Increased platelet aggregation and activation in psoriasis are linked to proinflammatory and proatherothrombotic pathways.
- The platelet transcriptome in psoriasis is associated with heightened cardiovascular risk.
- Platelet involvement warrants further investigation as a key factor in psoriasis-associated cardiovascular disease.
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