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Updated: Sep 9, 2025

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy
Published on: February 28, 2025
[Single digit nail clubbing]
Nieke N P M Smeins1,2, Tim Pruimboom1, Frank S van Leersum3
1Maastricht UMC+, afd. Plastische, Reconstructieve en Handchirurgie, Maastricht.
A rare subungual neurofibroma caused asymptomatic finger clubbing in a woman. Surgical removal successfully treated the condition, preserving the nail and digit.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Nail disorders can present with varied etiologies.
- Subungual tumors are uncommon causes of digital abnormalities.
- Neurofibromas typically affect nerve tissue but can occur in various locations.
Purpose of the Study:
- To report a case of subungual neurofibroma causing isolated digital clubbing.
- To highlight the diagnostic approach and successful management of this rare condition.
- To emphasize the importance of considering neoplastic causes for digital deformities.
Main Methods:
- Clinical presentation of a 33-year-old female with a progressive nail disorder.
- Magnetic Resonance Imaging (MRI) for subungual lesion characterization.
- Histopathological examination of the excised tumor for definitive diagnosis.
Main Results:
- A solitary, asymptomatic subungual neurofibroma was identified as the cause of left index finger clubbing.
- Surgical excision of the neurofibroma was performed.
- Complete recovery with preservation of nail and finger structure was achieved post-surgery.
Conclusions:
- Subungual neurofibroma is a rare but treatable cause of acquired digital clubbing.
- Multimodality diagnostic imaging and histopathology are crucial for accurate diagnosis.
- Conservative surgical management can yield excellent functional and aesthetic outcomes.
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