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The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
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Updated: Sep 9, 2025

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Bioretinoids from microalgae: Boosting retinol performance and tolerability.

Silvia Sánchez-Díez1,2, Alexandre Lapeyre1, Noemí García-Delgado1,2

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International Journal of Cosmetic Science
|September 4, 2025
PubMed
Summary
This summary is machine-generated.

A novel microalgae-derived bioretinoid (MBR) shows superior efficacy in skin regeneration and pigmentation control compared to retinol and bakuchiol. This MBR offers a gentler, more effective alternative for anti-aging and skin concerns.

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Area of Science:

  • Dermatology and Cosmetology
  • Biotechnology
  • Skin Science

Background:

  • Skin aging, hyperpigmentation, and texture issues are prevalent concerns.
  • Retinoids like retinol are effective but can cause irritation.
  • Bakuchiol is a plant-based alternative with a gentler profile.

Purpose of the Study:

  • To evaluate a novel microalgae-derived bioretinoid (MBR) against retinol and bakuchiol.
  • To assess MBR's efficacy in skin regeneration, anti-aging, and hyperpigmentation.
  • To compare the safety and effectiveness profiles of MBR.

Main Methods:

  • In vitro studies assessed cell proliferation, melanin production, and ECM modulation.
  • In vivo clinical trials evaluated skin texture, firmness, elasticity, and pigmentation.
  • MBR was compared against retinol and bakuchiol as reference treatments.

Main Results:

  • MBR demonstrated superior in vitro performance in cell proliferation, melanin reduction, and ECM modulation.
  • In vivo, MBR matched retinol's efficacy in improving skin texture, firmness, and pigmentation.
  • MBR enhanced retinol's benefits, boosting hydration and reducing irritation.

Conclusions:

  • MBR presents a potent alternative to traditional retinoids for skin regeneration and pigmentation.
  • The bioretinoid offers enhanced efficacy with a favorable safety profile.
  • Combining MBR with retinol may further improve skin hydration and reduce irritation.