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Published on: June 22, 2013
Investigation of the Effects of Dexpanthenol on Brain Tissue in Experimental Global Cerebral Ischemia-Reperfusion
Sarp Şah N1, Recai Eng N, Durmuş Emre Karatoprak
1Ministry of Health Karadeniz Eregli State Hospital Brain and Nerve Surgery Clinic, Zonguldak, Türkiye.
Aim:
To investigate the protective and therapeutic effects of dexpanthenol in experimental global cerebral ischemia-reperfusion injury.
Material And Methods:
Thirty-two female Wistar-Albino rats were used, and the rats were divided into four groups (sham, sschaemia reperfusion [IR], IR+dexpantol [IR+DXP] and DXP+IR), with eight animals in each group. At the end of 72 hours of reperfusion, the rats were decapitated after performing the rotarod and accelerrod tests, their brain tissues were removed and histopathologically examined, and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), and malonyldialdehyde (MDA) levels were evaluated.
Results:
In this study, motor skill functions deteriorated in the ischemia-reperfusion (IR) group compared to the sham group, while significant improvements were observed in both the IR+DXP and DXP+IR groups (p < 0.05). There were no notable differences in CAT, SOD, and GPx enzyme levels among the groups (p > 0.05); however, malondialdehyde (MDA) levels increased in the IR group and decreased significantly in the IR+DXP group (p < 0.05). Similarly, glutathione (GSH) levels were lower in the IR group but higher in the IR+DXP group (p < 0.05). Neuronal degeneration also significantly increased in the IR group but decreased in the IR+DXP group (p < 0.05).
Conclusion:
Overall, these findings suggest that dexpanthenol has a neuroprotective effect, particularly when administered during reperfusion, effectively improving motor skills and reducing neuronal damage.
