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Updated: Aug 10, 2026

Intramyocardial Cell Delivery: Observations in Murine Hearts
Published on: January 24, 2014
[The heart in the elderly. Pathology: macroscopic and light microscopy findings in the heart]
Insights
Heart weight increases with age, and age-related heart abnormalities, or polypathy, linearly increase with each decade. These changes heighten the risk of heart failure in older adults.
Area of Science:
- Gerontology
- Cardiology
- Pathology
Context:
- Aging is associated with significant cardiovascular changes.
- Understanding age-related cardiac morphology is crucial for geriatric care.
- Senile atrophy is not a confirmed phenomenon in the aging heart.
Purpose:
- To investigate the relationship between aging and heart morphology.
- To define and characterize "polypathy of the heart" in the elderly.
- To assess the functional consequences of age-related cardiac abnormalities.
Summary:
- Average heart weight increases up to the ninth decade.
- Morphological abnormalities, termed "polypathy of the heart," increase linearly with age.
- Key abnormalities include coronary sclerosis, small vessel disease, hypertrophy, calcification, and amyloidosis.
Impact:
- Polypathy of the heart increases vulnerability to heart insufficiency (latent or manifest).
- These findings have implications for the overall health of the aging organism.
- Highlights the importance of managing multiple cardiac conditions in the elderly.
Abstract:
The average heart weight increases up to the 9th decade. An existence of senile atrophy is not confirmed. Various morphological abnormalities of the heart in the elderly can be found during the course of life--polypathy of the heart. The number of these changes increases on average in each heart linearly with age. In polypathy of the heart the abnormalities which have functional consequences, such as stenosing coronary sclerosis, small vessel disease, heart hypertrophy, calcification of mitral ring and/or the aortic valves, as well as a cardiac amyloidosis are of the utmost importance. The polypathy of the heart in the elderly increases its vulnerability and may lead to a latent or manifest heart insufficiency. The law of polypathy is not only valid for the heart, but also for the whole organism.
Related Concept Videos
Pathophysiology of Heart Failure
Cardiovascular System Abnormal Findings I: Inspection and Palpation
Abnormal findings observed during an inspection
Myocarditis I: Introduction
Heart Failure I: Introduction
Heart Failure II: Pathophysiology
Cardiomyopathy III: Hypertrophic Cardiomyopathy

