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Updated: Sep 9, 2025
Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
Evolutionary patterns and future perspectives of joint replacement in arthritis patients: a comprehensive analysis of
Sha-Sha Tao1,2,3, Jian Tang1,2, Yu-Chen Liu4
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Purpose:
This study aimed to comprehensively review the current research status and trends of joint replacement for arthritis patients worldwide.
Methods:
Literature related to joint replacement for arthritis patients from 2004 to 2024 was extracted from the Web of Science Core Collection (WoSCC) database. A systematic qualitative and quantitative analysis of these publications was conducted. Visualization of results was achieved using CiteSpace and VOSviewer software.
Results:
In total, 14,349 publications met the inclusion and exclusion criteria and were selected for further research. Keyword analysis revealed a clinical emphasis on optimizing surgical outcomes through advancements in total knee arthroplasty, total hip arthroplasty, and patient-centered metrics. Emerging research hotspots since 2020 included precision techniques such as robotic-assisted surgery, strategies to address periprosthetic joint infection, and the role of psychological factors such as depression and patient satisfaction. Temporal trends highlighted evolving priorities, including personalized alignment protocols, where the burst intensities of kinematic alignment and mechanical alignment were 16.33 and 13.79, respectively, as well as functional recovery and complication prevention. Historical dominance of rheumatoid arthritis research has transitioned to broader exploration of osteoarthritis management and technological innovations in surgical precision.
Conclusion:
This study revealed a marked transition from rheumatoid arthritis-focused studies to innovations in osteoarthritis management and precision surgical techniques. Clinically, these findings emphasize the need to integrate technological advancements with multidisciplinary frameworks to standardize infection control, optimize implant durability, and enhance rehabilitation outcomes. Future efforts should prioritize personalized alignment strategies, evidence-based infection control protocols, and multidisciplinary rehabilitation frameworks to improve long-term functional outcomes.
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