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COVID-19 Pandemic-induced Healthcare Disruption and Chronic Kidney Disease Progression
Richard Liu1, Rahul Abraham2, Sarah E Conderino1
1Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Insights
The COVID-19 pandemic disrupted chronic kidney disease (CKD) care, reducing healthcare visits and accelerating kidney function decline in 2020. Post-pandemic care improvements may have slowed this decline.
Area of Science:
- Nephrology
- Public Health
- Epidemiology
Background:
- The COVID-19 pandemic significantly disrupted global healthcare systems.
- Patients with chronic kidney disease (CKD) faced unique challenges and potential care disruptions.
- Understanding pandemic's impact on CKD progression is crucial for future healthcare planning.
Purpose of the Study:
- To evaluate the impact of the COVID-19 pandemic on healthcare-seeking behavior in CKD patients.
- To assess the effect of pandemic-related care disruptions on CKD progression.
- To analyze trends in kidney function decline and healthcare visits among CKD patients in New York City.
Main Methods:
- Retrospective cohort study of 84,062 CKD patients (≥50 years) using electronic health records (2017-2022).
- Defined care disruption as fewer visits than recommended by Kidney Disease: Improving Global Outcomes (KDIGO) guidelines.
- Employed linear mixed-effects models to analyze estimated glomerular filtration rate (eGFR) changes and visit trends.
Main Results:
- Healthcare visits declined sharply in 2020, with incomplete recovery by 2022.
- A pronounced eGFR decline of 10.6% occurred in 2020, followed by slower declines.
- Patients with previously inadequate care showed increased visits during the pandemic, while others maintained recommended levels.
Conclusions:
- The COVID-19 pandemic disrupted CKD care, leading to reduced healthcare access and accelerated kidney function decline in 2020.
- Post-2020 improvements in kidney function decline may be linked to enhanced healthcare utilization and new therapeutic approaches.
- Findings highlight the vulnerability of CKD patients during public health crises and the need for resilient healthcare strategies.
Introduction:
The coronavirus disease 2019 (COVID-19) pandemic caused unprecedented disruptions to healthcare systems worldwide, significantly affecting patients with chronic kidney disease (CKD). In this study, we evaluated the impact of the pandemic on healthcare-seeking behavior and CKD progression among patients in New York City.
Methods:
Using electronic health records from PCORnet's INSIGHT Clinical Research Network, we conducted a retrospective cohort study focused on 84,062 patients with CKD aged 50 years or older with multiple chronic conditions seen between 2017 and 2022. Patients were identified using pre-pandemic CKD diagnostic codes, and confirmed by estimated glomerular filtration rate (eGFR) measurements. Care disruption was defined as receiving fewer visits than recommended by Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. We used linear mixed-effects models to estimate annual eGFR changes and analyze trends in care visits stratified by CKD stage and care disruption.
Results:
The study cohort had a mean age of 75.8 years, 43.2% were male, and mean pre-pandemic eGFR was 51.1 mL/min/1.73 m2. Care visits declined sharply in 2020 across patients at all but the end stage, with incomplete recovery by 2022. Patients with adequate pre-pandemic care maintained their visits above KDIGO levels, while those with inadequate care increased visits during the pandemic. Pronounced eGFR decline occurred in 2020 (10.6%), with slower declines observed thereafter.
Conclusion:
The COVID-19 pandemic disrupted CKD care, potentially leading to reduced healthcare-seeking behavior and accelerated kidney function decline in 2020. Slower decline post-2020 may reflect improved healthcare utilization, better medication adherence, and new therapies, and other factors.
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