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Related Experiment Video

Updated: Sep 9, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Psychological Vulnerability to Perinatal Depression: A Longitudinal Mediation Model.

Maria Provencio1, Maria F Rodríguez-Muñoz2, Katina Kovacheva3

  • 1Facultad de Psicología y Ciencias de la Salud, Universidad a Distancia de Madrid (UDIMA), Collado Villalba, Spain.

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PubMed
Summary

A history of depression indirectly increases the risk of postpartum depression (PPD), mediated by antenatal depression (AD) and neuroticism. Early screening for psychological vulnerability is crucial for preventing PPD.

Keywords:
antenatal depressionlongitudinal studymediation modelneuroticismpostpartum depression

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Area of Science:

  • Psychiatry
  • Psychology
  • Obstetrics

Background:

  • Perinatal depression (PD) encompasses antenatal depression (AD) and postpartum depression (PPD).
  • AD is a known risk factor for PPD.
  • Psychological vulnerability, including a history of depression and neuroticism, are key factors in PD.

Purpose of the Study:

  • To investigate the role of psychological vulnerability (history of depression, neuroticism) and AD as transdiagnostic risk factors for PPD.
  • To explore the mediating effects of neuroticism and AD on the relationship between a history of depression and PPD.

Main Methods:

  • Longitudinal study of 229 women.
  • Self-report questionnaires administered during pregnancy and postpartum.
  • Statistical analysis to determine indirect effects and mediation.

Main Results:

  • A history of depression significantly predicted PPD indirectly.
  • This indirect effect was mediated by both neuroticism and AD.
  • Neuroticism's role requires further longitudinal investigation due to potential fluctuations.

Conclusions:

  • A history of depression is a critical vulnerability factor for PPD, acting through neuroticism and AD.
  • Early identification of psychological vulnerability, especially a history of depression, is vital for preventing PD.
  • Targeted interventions for high-risk individuals, including those with high neuroticism during pregnancy, are recommended.