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Methodological Standards for Conducting High-Quality Systematic Reviews
Alessandro De Cassai1,2, Burhan Dost3, Serkan Tulgar4
1Department of Medicine (DIMED), University of Padua, 35127 Padua, Italy.
This guide details conducting high-quality systematic reviews in biological sciences, adapting clinical research principles. It covers protocol development, search strategies, data extraction, bias assessment, and reporting using PRISMA 2020 guidelines for transparent evidence synthesis.
Area of Science:
- Biology, health, and social sciences
- Adaptation of clinical research principles for biological sciences (ecology, molecular biology, evolutionary biology)
Background:
- Systematic reviews are crucial for evidence-based research.
- Existing guidelines are primarily focused on clinical research.
Purpose of the Study:
- To provide a detailed guide for conducting high-quality systematic reviews in biological sciences.
- To adapt and translate evidence-based review principles for biological research fields.
Main Methods:
- Protocol development and registration
- Comprehensive search strategy design and study selection
- Data extraction, risk of bias assessment, meta-analysis, and narrative synthesis
- Utilizing frameworks like GRADE for evidence certainty and PRISMA 2020 for reporting
Main Results:
- Outlines key steps for transparent and reproducible evidence syntheses.
- Highlights domain-specific methodologies, challenges, and resources for biological sciences.
- Emphasizes accurate data extraction and validated tools for bias assessment.
Conclusions:
- Provides tailored guidance for researchers in biological sciences.
- Facilitates the conduct of transparent and reproducible evidence syntheses in biology.
- Enhances the application of systematic review principles across diverse scientific disciplines.
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