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Burdock Tea Affects Pulmonary Microbiota and Physiology Through Short-Chain Fatty Acids in Wistar Rats.

Xiao-Feng Peng¹, Jing-Yi Zhu¹, Li-Zhi Cheng¹

¹College of Bioscience and Biotechnology, Yangzhou University, 48 East Wenhui Road, Yangzhou 225009, China.

|September 4, 2025

Summary

Burdock tea (BT) shows a nontoxic profile and may protect lung tissue by reducing oxidative stress and inflammation. It positively influences the gut microbiota and enhances short-chain fatty acids (SCFAs), supporting the gut-lung axis.

Keywords:

SCFAs antioxidant burdock tea gut–lung axis microbiota rat

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Area of Science:

Microbiology
Immunology
Pharmacology

Background:

The impact of burdock tea (BT) on lung protection and its effects on oxidative stress, inflammation, and microbiota are not well understood.
Research is needed to explore the potential health benefits of BT, especially in relation to the gut-lung axis.

Purpose of the Study:

To investigate the effects of BT on oxidative stress, inflammation, and gut and lung microbiota in healthy Wistar rats.
To determine the impact of BT on short-chain fatty acid (SCFA) production and related gene expression in the colon and lung.

Main Methods:

Wistar rats were treated with different doses of BT.
Analysis of cecal and lung microbiota composition and function.
Measurement of inflammatory markers, oxidative stress indicators, and SCFA levels.
Gene expression analysis of GPR43, NLRP3, ZO-1, and Occludin.

Main Results:

BT modulated the composition and function of cecal and lung microbiota, with dose-dependent effects.
BT treatment increased SCFA content and upregulated GPR43 and ZO-1 expression while suppressing NLRP3.
BT reduced serum IL-1β, IL-6, and tissue MDA levels, indicating reduced inflammation and oxidative stress.
SCFAs, particularly propionate and acetate, showed significant correlations with reduced oxidative stress, inflammation, and improved gut barrier function.

Conclusions:

Burdock tea (BT) demonstrates a nontoxic profile and potential lung-protective effects.
BT exerts its benefits through antioxidant and anti-inflammatory mechanisms, potentially mediated by SCFAs via the gut-lung axis.
The study highlights BT's capacity to modulate microbiota and enhance gut barrier integrity.