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Managing pressure ulcer risk in patients with diabetic neuropathy: a mechanobiological perspective for clinical
Bérengère Fromy1,2, Antoine Perrier3,4
1CNRS UMR 5305, Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, Lyon, France.
Abstract:
This article aims to highlight the mechanobiological determinants of foot ulcer risk in diabetic neuropathy. This condition alters sensorimotor control and blunts pressure-induced vasodilation, exposing soft tissues to sustained strain and ischaemia, even without visible deformity. This article presents a narrative clinical review supported by experimental mechanobiology and imaging case studies on diabetic neuropathy. It concludes that ulcer prevention should integrate vascular mechanobiology and biomechanic evaluation into personalised offloading strategies.
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