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Hematologic Variations in Children With Down Syndrome.

Golda Grinberg1, Gwen Sokoloff2, Beverly Hay2

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|September 4, 2025
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Summary
This summary is machine-generated.

Children with Down syndrome (DS) exhibit distinct complete blood count (CBC) ranges, including higher mean corpuscular volume and lower lymphocyte counts. These findings suggest benign hematologic variations in the DS population.

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blood countdown syndromehemoglobinlymphocytemean corpuscular volume

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Area of Science:

  • Pediatric Hematology
  • Genetics and Genetic Disorders
  • Clinical Pathology

Background:

  • Hematologic abnormalities in children with Down syndrome (DS) are documented but lack consistent conclusions.
  • Establishing reliable reference ranges for complete blood count (CBC) in DS is crucial for accurate clinical evaluation.
  • Previous studies present conflicting data regarding specific CBC parameters in pediatric DS populations.

Purpose of the Study:

  • To evaluate and define complete blood count (CBC) ranges specifically for children diagnosed with Down syndrome (DS).
  • To provide a clinical resource by presenting mean CBC values stratified by age and sex for pediatric DS patients.
  • To identify and characterize common hematologic variations observed in children with DS.

Main Methods:

  • Retrospective analysis of a single-institution cohort.
  • Evaluation of complete blood count (CBC) data from pediatric patients with Down syndrome (DS).
  • Comparison of observed CBC parameters against established reference values.

Main Results:

  • Children with Down syndrome (DS) demonstrated higher mean corpuscular volume (MCV) compared to reference values.
  • A lower absolute lymphocyte count was consistently observed in the pediatric DS cohort.
  • A trend toward higher hemoglobin (Hgb) values was noted in children with DS.

Conclusions:

  • The identified hematologic findings (elevated MCV, reduced lymphocytes, higher Hgb trend) appear to be consistent variations in children with Down syndrome (DS).
  • These variations are suggested to be benign, representing characteristic hematologic profiles in the DS population.
  • The study provides essential data for the accurate interpretation of CBC results in pediatric DS evaluations.