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Published on: May 21, 2019
Photocatalyst-Free Visible-Light-Induced Decarbonylation/Truce-Smiles Rearrangement Cascade to Access
Han-Chi Liu1, Chun-Lin Dong1, Zhi Guan1
1Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
None:
A visible-light-induced decarbonylation/Truce-Smiles rearrangement cascade has been developed for the direct synthesis of 2-aminobenzophenones. This protocol employs readily available isatins and sulfonyl chlorides as starting materials, enabling the construction of diverse 2-aminobenzophenone derivatives under mild conditions without the need for transition metal catalysts or photocatalysts. The reaction exhibits a broad substrate scope, excellent functional group tolerance, and high efficiency. A total of 32 derivatives were synthesized with yields that reached 99%. The practicality of this approach was further demonstrated through a gram-scale reaction, highlighting its potential for synthetic applications.
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The carbonyl center is...
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