Evaluation of Tp-e interval, Tp-e/QT and Tp-e/QTc ratios in patients with hypertensive crisis

Area of Science:

• Cardiology
• Electrophysiology
• Hypertension Research

Background:

• Hypertensive crisis (HC) is a known risk factor for cardiac arrhythmias.
• Early identification of arrhythmia risk in HC is crucial for patient management.

Purpose of the Study:

• To evaluate Tp-e interval, Tp-e/QT ratio (TQR), and Tp-e/QTc ratio (TQcR) in patients with hypertensive urgency and emergency.
• To assess the potential risk of ventricular arrhythmias associated with these ECG parameters in HC.

Main Methods:

• Prospective study of 235 patients with hypertensive crisis (urgency, emergency) and a control group.
• Collected demographic, vital signs, laboratory, and electrocardiography (ECG) data, including Tp-e, TQR, and TQcR.
• Statistical analysis to compare ECG parameters across groups and correlate with blood pressure.

Main Results:

• Significant differences in Tp-e, TQR, and TQcR values were found across all study groups (p < 0.001).
• These ECG metrics showed moderate positive correlations with both systolic and diastolic blood pressures.
• Elevated values of Tp-e, TQR, and TQcR were observed in patients experiencing hypertensive crisis.

Conclusions:

• Increased Tp-e, TQR, and TQcR values in hypertensive crisis patients suggest a heightened risk for ventricular arrhythmias.
• Routine ECG evaluation of these parameters may aid in identifying patients at risk.
• These findings underscore the importance of monitoring cardiac electrophysiology during hypertensive crises.