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Related Concept Videos

Effects of EDTA on End-Point Detection Methods01:18

Effects of EDTA on End-Point Detection Methods

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Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
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Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring
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Analysis of explanted Essure® devices.

Léna Christ1, Thomas Boisramé2, Nicole Neumann1

  • 1GEPROMED, 4 Rue Kirschleger, 67000 Strasbourg, France.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|September 4, 2025
PubMed
Summary
This summary is machine-generated.

Explanted Essure® devices show significant deformation and the presence of tin. This suggests tin may play a role in adverse symptoms, warranting further investigation into its biological impact.

Keywords:
Atomic compositionDegradationEssure®Explant analysisGynecologic

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Area of Science:

  • Biomaterials Science
  • Medical Device Analysis
  • Toxicology

Background:

  • Essure® is a permanent female sterilization device.
  • Understanding the in-vivo behavior of medical implants is crucial for patient safety.
  • Previous studies have raised concerns regarding Essure® complications.

Purpose of the Study:

  • To investigate the atomic composition and structural changes of explanted Essure® devices.
  • To correlate elemental findings with macroscopic and microscopic observations.
  • To explore the potential role of device components in adverse patient symptoms.

Main Methods:

  • Analysis of 50 explanted Essure® devices using microscopy and spectral analysis.
  • Elemental analysis of device components divided into inner, main, and outer coils.
  • X-ray Faxitron imaging to assess structural integrity.

Main Results:

  • Explanted devices exhibited significant stretching and deformation.
  • Calcification and biological tissue encapsulation were observed.
  • Tin was a predominant element across all analyzed zones, alongside other metals; calcium was also detected.

Conclusions:

  • The presence and distribution of tin in Essure® devices suggest its potential involvement in adverse symptom development.
  • Further research is recommended to elucidate the role of tin in the pathogenesis of patient complications.
  • Findings underscore the importance of material analysis in understanding medical device-related health issues.