Immunoinformatics-guided vaccine design: A review with case study on Marburg virus

A primary concern for world health is the emergence of new infectious diseases. Conventional vaccine development techniques are time-consuming and often limited by issues such as antigen availability and safety concerns. Immunoinformatics, a computational approach that integrates immunology and informatics, presents a promising solution for accelerating vaccine design. Researchers can rapidly identify potential vaccine candidates by leveraging computational tools and databases, predict their immunogenicity and safety profiles, and optimize their design. This review explores immunoinformatics approaches for vaccine design and illustrates them through a case study on the Marburg virus. We highlight the tools and databases involved to expedite the vaccine development process and improve global health outcomes. The designed vaccine exhibited desirable physicochemical and biological interaction results. This review on the use of the immunoinformatics approach to enhance vaccine development against emerging infectious diseases provides an efficient first step in the vaccine development process.