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Two new polyketides and a new γ-lactone-derived furanone from a soil fungus Trichoderma spirale BHM2-5
Joon Su Jang1, Jae Sang Han1, Yong Beom Cho1
1College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
Abstract:
Two previously undescribed polyketides, bukhansanketides A (1) and B (2), along with a γ-lactone-derived furanone, (S)-(-)-bukhansanfuranone (3), were isolated from Trichoderma spirale BHM2-5, together with four known compounds (4-7). Their structures were elucidated by 1D and 2D NMR spectroscopy and HR-ESI-MS data, as well as DP4+ probability analysis, the modified Mosher's method, or VCD calculations. All isolated compounds (1-7) were evaluated for their cytotoxic activities against A549, SK-OV-3, and HCT-8 cancer cell lines. Among them, compound 6 exhibited cytotoxic effect against HCT-8 cells, with IC₅₀ value of 44.2 ± 5.5 μM.
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