Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

6.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.2K
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

722
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
722
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

853
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
853
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

893
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
893

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multicenter validation of plasma p-tau217/ amyloid beta 1-42 ratio in symptomatic Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Decreased awareness of cognitive decline is associated with multimodal Alzheimer's disease biomarkers in cognitively unimpaired individuals.

Neurobiology of aging·2026
Same author

Plasma phosphorylated tau217 discordance with amyloid status in an ethnically diverse mixed memory clinic cohort.

Journal of the neurological sciences·2026
Same author

Multimodal biomarker characterization of amnestic objective subtle cognitive decline in aging and preclinical Alzheimer's disease.

The journal of prevention of Alzheimer's disease·2026
Same author

Plasma eMTBR-tau243 and %p-tau217 for Biological Staging of Alzheimer Disease.

JAMA neurology·2026
Same author

Tau-PET and CSF MTBR-tau243 comparisons validate increased tau aggregation in females.

European journal of nuclear medicine and molecular imaging·2026

Related Experiment Video

Updated: Apr 30, 2026

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

12.3K

Evaluation of a Sensitive Visual Read Algorithm for Assessing 3R/4R Tau PET Images.

Ruben Smith1,2, Valentina Garibotto3,4,5, Douglas Hägerström6

  • 1Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden; ruben.smith@med.lu.se.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|September 4, 2025
PubMed
Summary

The BioFINDER visual read (BF-VR) algorithm accurately detects Alzheimer's disease-related tau in PET scans, outperforming the [18F]flortaucipir visual read (FTP-VR) in the entorhinal cortex. BF-VR also demonstrated excellent reliability for clinical use.

Keywords:
ADbiomarkersdiagnostic accuracytau PETvisual read

More Related Videos

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

3.8K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

542

Related Experiment Videos

Last Updated: Apr 30, 2026

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

12.3K
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

3.8K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

542

Area of Science:

  • Neuroimaging
  • Alzheimer's Disease Diagnostics
  • Radiopharmaceutical Imaging

Background:

  • Accurate assessment of Alzheimer's disease (AD)-related tau in tau Positron Emission Tomography (PET) imaging is crucial for clinical trials and practice.
  • Visual read algorithms are being developed to interpret tau PET scans, necessitating validation against quantitative measures and biomarkers.

Purpose of the Study:

  • To compare the accuracy of two visual read algorithms (BioFINDER visual read [BF-VR] and [18F]flortaucipir visual read [FTP-VR]) for tau PET imaging.
  • To evaluate these algorithms against semiquantitative measurements and plasma phospho-tau 217 (p-tau217) status.
  • To assess the reliability of the BF-VR algorithm.

Main Methods:

  • 1,654 participants from the BioFINDER-2 cohort underwent [18F]RO948 PET scans; 37 also had [18F]flortaucipir scans.
  • PET scans were analyzed using the BF-VR protocol and the established FTP-VR method.
  • Comparative analyses included semiquantitative SUV ratios (SUVRs) in the entorhinal cortex (ERC) and temporal meta-region, and plasma p-tau217 status.

Main Results:

  • Both visual read methods showed strong concordance with semiquantitative SUVRs.
  • BF-VR demonstrated superior accuracy for tau in the ERC (93.9%) compared to FTP-VR (89.9%).
  • BF-VR exhibited excellent interrater (κ=0.87) and intrarater (κ=0.94) reliability, with high concordance between [18F]RO948 and [18F]flortaucipir assessments (κ=0.94).

Conclusions:

  • Visual reads provide a simple method for evaluating tau PET scans.
  • The BF-VR algorithm is a more accurate method for detecting tau uptake in the ERC than FTP-VR.
  • BF-VR shows excellent reliability and comparable performance with different tau PET tracers ([18F]RO948 and [18F]flortaucipir).