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Combination Therapy Involving Pulsed Dye and Fractional CO2 Laser Followed by Ultrasound-Assisted Transdermal Drug
Zhongliang Lang1,2, Guangdi Yin1, Qiusheng Zhang1
1Department of Plastic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, P.R. China.
Insights
This study shows that a combination of pulsed dye and fractional CO2 laser with ultrasound-assisted drug delivery effectively treats pediatric hypertrophic scars. The treatment offers high satisfaction and minimal side effects for children.
Area of Science:
- Dermatology
- Medical Technology
- Pediatric Care
Background:
- Hypertrophic scarring is a common, clinically significant condition in children, often impairing function.
- Effective treatment options for pediatric hypertrophic scars are limited.
- Current treatments may not adequately address the unique challenges in pediatric scar management.
Purpose of the Study:
- To evaluate the efficacy of combined pulsed dye and fractional CO2 laser therapy with ultrasound-assisted transdermal drug delivery for pediatric hypertrophic scars.
- To assess the safety and patient satisfaction of this combined treatment modality.
- To provide evidence for an improved therapeutic approach in pediatric scar treatment.
Main Methods:
- A retrospective cohort study with a self-controlled before-and-after design.
- 36 pediatric patients (ages 2-17) with 41 hypertrophic scars received combined laser and ultrasound-assisted triamcinolone acetonide treatment.
- Scar assessment using Patient and Observer Scar Assessment Scale (POSAS) at baseline and 6/12 months post-treatment; family satisfaction evaluated.
Main Results:
- Significant reduction in total POSAS scores (74.3±4.7 to 23.6±2.9, P<0.001) at 12 months post-treatment.
- High overall patient satisfaction rate of 98%.
- No serious adverse reactions were reported during the follow-up period.
Conclusions:
- Combined pulsed dye and fractional CO2 laser with ultrasound-assisted transdermal drug delivery is highly effective for pediatric hypertrophic scars.
- This treatment modality demonstrates excellent therapeutic outcomes, minimal discomfort, and high patient compliance.
- The approach is safe and well-tolerated in pediatric patients, offering a promising solution for scar management.
Background:
Hypertrophic scarring is a common pathological condition often associated with significant clinical symptoms. In pediatric patients, it can impair function and is difficult to treat due to the limited availability of effective treatment options.
Objective:
To investigate the efficacy of pulsed dye and fractional CO2 laser combined with ultrasound-assisted transdermal drug delivery technology in the treatment of hypertrophic scars in pediatric patients.
Methods:
A retrospective cohort study and a self-controlled before-and-after method were used. Thirty-six patients with 41 sites of hypertrophic scars who visited our hospital between July 2022 and December 2023 were included, comprising 18 males and 18 females, aged 2-17 years. All patients underwent a combination of pulsed dye and fractional CO2 laser treatment, followed by the triamcinolone acetonide using ultrasound-assisted transdermal drug delivery technique. A second combined treatment was performed after an interval of 6-8 weeks. Scars were assessed by physicians and parents using the Patient and Observer Scar Assessment Scale (POSAS) before the first treatment, and at 6 and 12 months after the final treatment. Family satisfaction with treatment efficacy was evaluated at both 6 and 12 months post-treatment, and overall satisfaction was documented at each follow-up.
Results:
The study revealed a notable decline in the total patient and observer scar scale scores (74.3±4.7 versus 23.6±2.9), with a P-value of less than 0.001 for each specific POSAS score item at the 12 months follow-up period in comparison to the baseline. The overall satisfaction rate was 98%, and no serious adverse reactions were observed during the follow-up period.
Conclusion:
Pulsed dye and fractional CO2 laser combined with ultrasound-assisted transdermal drug delivery technique demonstrates excellent therapeutic efficacy in the treatment of hypertrophic scars in children. The treatment is associated with minimal discomfort, high patient compliance, and no significant adverse reactions.
Level Of Evidence Iv:
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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