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Multi-system benefits of non-invasive spinal cord stimulation following cervical spinal cord injury: a case study

Soshi Samejima1,2,3, Claire Shackleton4,5, Raza N Malik4,5

  • 1International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada. soshis@uw.edu.

Bioelectronic Medicine
|September 4, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Autonomic dysfunctionMotor functionSpinal cord injuryTranscutaneous spinal cord stimulation

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Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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