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Published on: January 7, 2018
Feimin in Glucose Homeostasis: Mechanistic Insights, Population Heterogeneity, and Therapeutic Potential
1Huangshi Key Laboratory of Birth Defects Prevention, Department of Laboratory Medicine, Huangshi Maternity and Children's Health Hospital, Affiliated Maternity and Children's Health Hospital of Hubei Polytechnic University, Huangshi, 435000, Hubei, People's Republic of China.
Abstract:
The recent discovery of feimin, a feeding-induced myokine modulating glucose homeostasis via the MERTK pathway, offers a novel therapeutic avenue for metabolic disorders. While other studies delineate its acute metabolic effects in Han Chinese populations, critical gaps remain in understanding its mechanistic interplay, population generalizability, and long-term impacts. This perspective synthesizes current evidence, highlights limitations in study design and translational applicability, and proposes integrative approaches, spanning multi-omics, global consortia, and interventional trials, to unravel feimin's role in metabolic regulation. By addressing these challenges, feimin may emerge as a biomarker or therapeutic target for diabetes and related syndromes.
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