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Updated: May 13, 2026
Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
Published on: July 25, 2011
Three-Dimensional Presentation of Tongue Squamous Cell Carcinoma Histopathology and Magnetic Resonance Imaging-A
Anne Koivuholma1,2, Heli J Sistonen3, Katri Aro1
1Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Background:
Three-dimensional (3D) modeling has been used in the management of bony head and neck tumors, but not in soft tissue tumors. Currently, histopathological findings of oral squamous cell carcinomas (OSCC) are presented as two-dimensional images. Previously, we developed a 3D image fusion method that presents tumor histopathology and MRI in 3D form. In this study, we sought to test our method in a series of OSCCs.
Methods:
A 3D table scanner, 3D Slicer software, and 3D modeling software were used to produce 3D image fusions of nine OSCCs.
Results:
Nine OSCCs are presented as digital, 3D image fusions, showing the resected specimen and the tumor within based on histopathology and MRI.
Conclusions:
The fused 3D model allows for a better visual understanding of tumor orientation within the resected specimen, provides a tool to compare tumor volume and dimensions between MRI images and histopathology slides, and facilitates multidisciplinary discussion.
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