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A Retrospective Analysis of Itch Intensity and Comorbidities in Lichen Simplex Chronicus
Kayla D Mashoudy1, Joselyn Ye-Tay2, Sarah Kim1
1Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, USA.
Acta Dermato-Venereologica
|September 5, 2025
Summary
Lichen simplex chronicus causes severe daily itch, often on limbs. This skin condition frequently co-occurs with anxiety, depression, hypertension, and diabetes, impacting patient quality of life.
Area of Science:
- Dermatology
- Psychiatry
- Internal Medicine
Background:
- Lichen simplex chronicus is a chronic pruritic skin condition.
- It significantly impacts patients' quality of life.
Purpose of the Study:
- To characterize itch severity, anatomical distribution, and comorbidities in lichen simplex chronicus.
- To analyze data from 125 patients at a tertiary academic center.
Main Methods:
- Retrospective analysis of 125 patients with clinically confirmed lichen simplex chronicus.
- Itch intensity assessed using the Numerical Rating Scale (NRS).
- Clinical data stratified by demographics and disease extent.
Main Results:
- 75% of patients reported moderate-to-severe itch (NRS 4-10).
- Nearly 90% experienced daily pruritus; half had daytime and nocturnal symptoms.
- High prevalence of comorbidities: generalized anxiety disorder (50%), major depressive disorder (44%), hypertension (61%), and type 2 diabetes (30%).
- Multiple-lesion lichen simplex chronicus associated with higher itch severity and female predominance.
Conclusions:
- Lichen simplex chronicus presents a high symptom burden with frequent psychiatric and metabolic comorbidities.
- Early identification and management of associated conditions are crucial.
- Integrated care approaches may improve patient outcomes.
