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Updated: Sep 9, 2025

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Intestinal aging-related immune dysfunction: mechanisms and interventions.

Xin Shen1,2, Xianzhi Gao2, Lie Wang2,3,4

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Acta Biochimica Et Biophysica Sinica
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Intestinal immunosenescence, or gut immune aging, affects elderly health. This review explores its mechanisms, health links, and new therapies to improve aging well.

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Area of Science:

  • Gerontology
  • Immunology
  • Gastroenterology

Background:

  • Intestinal immunosenescence is a key aspect of aging, impacting elderly health.
  • Aging alters gut immune cells, microbiota balance, and barrier integrity.
  • These changes are linked to age-related diseases.

Purpose of the Study:

  • To systematically review mechanisms of intestinal immunosenescence.
  • To analyze its association with diseases like infections and neurodegeneration.
  • To summarize current and emerging therapeutic strategies.

Main Methods:

  • Literature review of scientific articles on intestinal immunosenescence.
  • Analysis of immune cell function, microbiota, and barrier changes.
  • Synthesis of data on disease associations and interventions.

Main Results:

  • Immune cell dysfunction, dysbiosis, and barrier defects characterize intestinal immunosenescence.
  • It is associated with increased susceptibility to infections, chronic inflammation, and neurodegenerative conditions.
  • Dietary and microecological therapies show promise.

Conclusions:

  • Understanding intestinal immunosenescence is crucial for aging well.
  • Targeting gut immunity offers potential for healthspan extension.
  • Future research should focus on precision interventions for gut health in the elderly.