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Exosomes in obstructive sleep apnea-related diseases
Zhifeng Chen1,2,3,4, Yulin Shang5, Yanru Ou1,2,3,4
1Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Chinese Medical Journal
|September 5, 2025
Summary
Obstructive sleep apnea (OSA) involves airway collapse, increasing disease risk. This review explores how exosomes, tiny cell messengers, contribute to OSA-related illnesses and potential new therapies.
Area of Science:
- Cellular Biology
- Sleep Medicine
- Pathophysiology
Background:
- Obstructive sleep apnea (OSA) is a prevalent condition linked to numerous severe health issues.
- Intermittent hypoxia during OSA disrupts normal bodily functions.
- Exosomes are crucial for cell-to-cell communication, carrying various biomolecules.
Purpose of the Study:
- To review the role of exosomes in diseases associated with obstructive sleep apnea.
- To explore the mechanisms by which exosomes contribute to OSA pathogenesis.
- To highlight exosome-based therapeutic strategies for OSA-related conditions.
Main Methods:
- Literature review of studies on obstructive sleep apnea and exosomes.
- Analysis of exosome biogenesis, cargo, and function in OSA.
- Examination of exosome-mediated intercellular communication in disease models.
Main Results:
- Altered circulating exosomes in OSA patients.
- Exosomes contribute to cellular dysfunction in OSA-related diseases.
- Exosomal microRNAs, proteins, and lipids play roles in disease progression.
Conclusions:
- Exosomes are implicated in the development and progression of OSA-associated diseases.
- Understanding exosome function offers insights into OSA pathophysiology.
- Exosome-based therapies present a promising avenue for treating OSA complications.
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