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Updated: Sep 9, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Serum uric acid to high-density lipoprotein cholesterol ratio is associated with stroke in the elderly: a
Qingsong Jiang1, Guoyong Zhan1, Yi Liu2
1Department of Neurosurgery, QuZhou KeCheng People's Hospital, Quzhou, China.
Purpose:
The ratio of serum uric acid (UA) to high-density lipoprotein cholesterol (HDL-c), known as UHR, has been identified as a novel marker for oxidative stress and metabolic disorders. This study focused on exploring the association between UHR and stroke risk among older adults in the United States.
Methods:
This cross-sectional study utilized data from individuals aged 60 years and older, collected through the 1999-2018 National Health and Nutrition Examination Survey (NHANES). Stroke assessment was based on participants' self-reported history. The association between UHR and stroke risk was analyzed using logistic regression, restricted cubic splines (RCS), subgroup analysis, and receiver operating characteristic (ROC) curves.
Results:
This study included a total of 16,562 older adults, and the proportion of stroke cases increased with higher UHR levels. After adjusting for confounders, multivariable logistic regression analysis revealed that individuals in the highest UHR quartile had an odds ratio of 1.48 (1.23-1.80) for stroke risk compared to those in the lowest quartile. Subgroup analyses further demonstrated a stronger association in non-diabetic populations. RCS analysis suggested a linear relationship. Based on ROC results, UHR outperformed UA and HDL-c.
Conclusion:
Higher UHR levels are strongly associated with an increased risk of stroke in older adults. Additional large-scale prospective studies are required.
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