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Phosphatases in human seminal plasma.

J A Székely, F Zernig, G N Than

    International Journal of Fertility
    |January 1, 1979
    PubMed
    Summary
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    Alkaline and acid phosphatase levels in semen were similar between fertile and infertile men. These enzyme activity measurements are not recommended for clinical use due to lack of correlation with sperm count.

    Area of Science:

    • Biochemistry
    • Reproductive Biology
    • Urology

    Background:

    • Alkaline phosphatase and acid phosphatase are enzymes found in seminal fluid.
    • Their activity may potentially correlate with male fertility parameters.

    Purpose of the Study:

    • To investigate the correlation between alkaline and acid phosphatase activity in ejaculate and sperm density.
    • To compare enzyme activity in fertile versus infertile males.

    Main Methods:

    • Enzyme activity assays for alkaline and acid phosphatase were performed on ejaculates.
    • Semen samples were obtained from normospermic (fertile), oligospermic (low sperm count), and azoospermic (no sperm) males.

    Main Results:

    • No significant correlation was observed between sperm density and alkaline or acid phosphatase activity.

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  • Enzyme activity levels were found to be comparable between fertile and infertile male groups.

    • Conclusions:

    • Alkaline and acid phosphatase activity measurements in ejaculate do not appear to be reliable indicators of male fertility.
    • Routine clinical use of these enzyme assays for fertility assessment is not recommended.