Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dosage Regimen Designs: Nomograms and Tabulations01:23

Dosage Regimen Designs: Nomograms and Tabulations

Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal trajectories in multidomain frailty among patients with chronic kidney disease.

Journal of nephrology·2026
Same author

Political Ideology and HPV Vaccine Awareness: Sex Differences and Nursing Implications Using the Health Information National Trends Survey (HINTS).

Nursing research and practice·2026
Same author

Multi-omics pleiotropic association analyses reveal functionally relevant genes and druggable pathways for ovarian aging.

Genome biology·2026
Same author

Prognostic nomogram for acute cerebral infarction based on risk factors: treatment with urinary kallidinogenase and edaravone-dexborneol.

American journal of translational research·2026
Same author

The association between acute nutritional changes and prognosis in ischemic stroke patients.

Frontiers in nutrition·2026
Same author

Group-based psychoeducation for dissociative disorders: Reducing PTSD and dissociative symptoms while enhancing emotion regulation and adaptive capacity.

Psychological trauma : theory, research, practice and policy·2026

Related Experiment Video

Updated: May 9, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

22.0K

A nomogram for predicting early thrombolytic efficacy in stroke patients.

Chen Lou1, Dongjuan Xu1

  • 1Department of Neurology, Dongyang People's Hospital, Affiliated to Wenzhou Medical University, Dongyang, China.

Frontiers in Neurology
|September 5, 2025
PubMed
Summary

This study developed a nomogram to predict early thrombolytic efficacy in stroke patients. The model uses age, NIHSS score, prothrombin time, neutrophil, and monocyte counts for better treatment decisions.

Keywords:
cerebral infarctionearly thrombolytic efficacyintravenous thrombolysisischemic strokenomogram

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.1K
An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

2.8K

Related Experiment Videos

Last Updated: May 9, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

22.0K
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.1K
An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

2.8K

Area of Science:

  • Neurology
  • Medical Informatics
  • Biostatistics

Background:

  • Intravenous thrombolysis is a critical treatment for acute ischemic stroke.
  • Predicting early treatment response is essential for optimizing patient outcomes.
  • Current prediction methods for thrombolytic efficacy in stroke are limited.

Purpose of the Study:

  • To develop and validate a novel nomogram for predicting early thrombolytic efficacy in stroke patients.
  • To identify key clinical variables associated with successful thrombolysis.
  • To provide a tool for enhanced clinical decision-making in stroke management.

Main Methods:

  • Retrospective collection of clinical data from stroke patients receiving intravenous thrombolysis.
  • Development of a predictive nomogram using LASSO and multivariate logistic regression.
  • Assessment of model performance using Area Under the Curve (AUC), calibration, and decision curve analysis.

Main Results:

  • A nomogram incorporating age, pre-thrombolysis NIHSS score, prothrombin time, neutrophil count, and monocyte count was developed.
  • The model demonstrated good discriminatory power with AUCs of 0.761 (training set) and 0.744 (test set).
  • Decision curve analysis indicated clinical utility within specific probability thresholds for both datasets.

Conclusions:

  • The developed nomogram is a promising tool for predicting early thrombolytic efficacy in stroke patients.
  • The identified predictors (age, NIHSS, prothrombin time, neutrophil, monocyte counts) are crucial for treatment response.
  • This nomogram can aid physicians in making more informed therapeutic decisions for stroke patients undergoing thrombolysis.