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Updated: Sep 9, 2025

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A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
551
Drug-Induced Toxic Epidermal Necrolysis: A Case Report
Tânia Pereira da Silva1, Maria Luis Santos1, Ana Patrícia Brito1
1Internal Medicine, Unidade Local de Saúde do Alto Ave, Guimarães, PRT.
Cureus
|September 5, 2025
Summary
Toxic epidermal necrolysis (TEN) is a severe drug reaction. This case highlights ibuprofen, an over-the-counter NSAID, as a potential trigger in elderly patients, emphasizing prompt recognition and drug cessation for better outcomes.
Area of Science:
- Dermatology
- Pharmacology
- Internal Medicine
Background:
- Toxic epidermal necrolysis (TEN) is a rare, life-threatening mucocutaneous drug reaction with high mortality, especially in the elderly.
- Commonly implicated drugs include antibiotics, anticonvulsants, NSAIDs, and allopurinol.
- Prognosis is influenced by age, comorbidities, and extent of skin involvement (TBSA).

