Related Experiment Video
Updated: May 5, 2026

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
Published on: October 12, 2016
Design of a general type BSSO fixation plate integrating topology and parameter optimization for various severity
Chun-Ming Chang1, Po-Fang Wang2,3, Yu-Tzu Wang4
1National Center for Instrumentation Research, National Institutes of Applied Research, Hsinchu, Taiwan.
Introduction:
Patients with hemifacial microsomia exhibit varying degrees of mandibular asymmetry. The commercial plates used during bilateral sagittal split osteotomy (BSSO) surgery are often not tailored to individual patients and may lack sufficient fixation stability, increasing the risk of mandibular relapse. This study proposes a patient-specific plate design by collecting CT images of 30 cases of hemifacial microsomia to statistically analyze mandibular asymmetry.
Methods:
The design process integrates topology and parameter optimization analysis to develop the plate (TOPO plate), aiming for a lightweight structure with enhanced fixation stability. The structural strength and fixation stability of the TOPO plate were verified through static and dynamic four-point bending tests, as well as biomechanical testing, ensuring compliance with clinical requirements and regulatory approval for market release.
Results:
The TOPO plate features an asymmetrical design tailored to patient's specific anatomy. In static/dynamic four-point bending tests, the structural strength of the TOPO plate exceeded that of commercial plates, with average proof loads of 326.9N for the right side and 389.85N for the left side. Biomechanical analysis and testing confirmed that the TOPO plate effectively limits the displacement of the mandibular segment (average 0.45mm), providing favorable fixation stability and thereby reducing the risk of relapse.
Discussion:
In summary, the TOPO plate is applicable for most patients with hemifacial microsomia, meeting the biomechanical requirements of the mandible and complying with market conditions. This patient-specific approach promises improved outcomes in mandibular fixation stability.
Related Concept Videos
Imaging Biological Samples with Optical Microscopy
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Phase Contrast and Differential Interference Contrast Microscopy
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
Confocal Fluorescence Microscopy

