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Multimodal neuroimaging of fatigability development.

Patrick Bedard1, Kristine M Knutson2, Patrick M McGurrin1

  • 1Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.

Imaging Neuroscience (Cambridge, Mass.)
|September 5, 2025
PubMed
Summary
This summary is machine-generated.

Neuromuscular fatigability involves central and peripheral factors. This study used neuroimaging to show that changes in the neuromuscular system, particularly peripheral fatigue, occur before a drop in grip force performance.

Keywords:
EEGEMGcorticomuscular coherencefMRIfatigability

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Area of Science:

  • Neuroscience
  • Human Physiology
  • Motor Control

Background:

  • Fatigability, the neuromuscular system's inability to meet task demands, has central and peripheral origins, but their interaction during fatigue development is unclear.
  • Understanding fatigability is crucial as it affects healthy individuals and exacerbates symptoms in various disorders.

Purpose of the Study:

  • To investigate the development of fatigability in the neuromuscular system using multimodal neuroimaging.
  • To explore the interplay between central and peripheral fatigue mechanisms during sustained motor tasks.

Main Methods:

  • Healthy participants performed a fatiguing grip force task while undergoing simultaneous electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and electromyography (EMG) of forearm muscles.
  • Corticomuscular coherence (EEG-EMG) and EEG-informed fMRI were computed to analyze neuromuscular adaptations and brain activity changes.
  • Data were analyzed across task blocks representing pre-fatigability and actual fatigability states.

Main Results:

  • Changes in the neuromuscular system, including EMG frequency shifts and increased EEG/fMRI signals in sensorimotor and cerebellar areas, preceded decrements in grip force.
  • Corticomuscular coherence increased within task blocks, suggesting enhanced neural drive.
  • EEG-informed fMRI identified key brain regions like the sensorimotor cortex and supplementary motor area involved in fatigue adaptation.

Conclusions:

  • Neuromuscular adaptations occur earlier than behavioral changes during fatigability development.
  • Evidence suggests both central and peripheral fatigue contribute, with peripheral fatigue appearing to manifest first.
  • Multimodal neuroimaging provides novel insights into the complex mechanisms underlying fatigability.