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One year monitoring of calcium release from an experimental composite containing calcium phosphate particles
Handially Vilela1, Mariana Nakamura1, Roberto Braga1
1Department of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Introduction:
Ca2+ release from specimens made of a composite containing dicalcium phosphate dihydrate particles (CaHPO4.2H2O, dicalcium phosphate dihydrate [DCPD]) was followed during 1 year.
Methods:
Specimens were individually immersed in deionized water (n = 3). Every 2 weeks, immersion medium was collected and specimens were transferred to new vials with fresh medium. Ca2+ release was quantified using induced coupled plasma-optical emission spectrometry (ICP-OES). Data were analyzed by ANOVA/Tukey test (alpha: 5%).
Results:
Ca2+ release was observed during the entire 12-month period. Cumulative release was 1635.1 ± 145.3 μg/cm2 (179.7 ± 16.0 ppm), corresponding to 23.8 ± 2.0% of the total Ca mass in the specimen.
Conclusion:
The tested composite was capable of sustained Ca2+ release in water for 1 year. In spite of the limitations of this screening test, the results suggest that composites containing Calcium phosphate (CaP) particles could offer a long-term Ca2+ supply to the adjacent dental tissues.
