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Updated: Sep 9, 2025

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

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Published on: November 17, 2023

Bacteriological Identification, Characterization and Changes of Feces Microbiome in Prostate Cancer Patients

Aleksandra Bogumiła Florkiewicz¹, Paweł Fijałkowski¹, Piotr Fijałkowski¹

¹Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University in Torun, Torun, Poland.

Cancer Management and Research

|September 5, 2025

Summary

Radiation therapy significantly alters the gut microbiome in prostate cancer patients, decreasing beneficial bacteria and increasing opportunistic pathogens. These changes correlate with altered blood markers, impacting patient health.

Keywords:

fecal matrix-assisted laser desorption/ionization time-of-flight microbiome microorganisms prostate cancer

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

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Published on: November 2, 2013

Area of Science:

Microbiology
Oncology
Gastroenterology

Background:

The gut microbiome plays a crucial role in overall health and disease.
Prostate cancer (PCa) treatment, including radiation therapy, can impact systemic health.
Understanding the gut microbiome's response to PCa treatment is essential for patient care.

Purpose of the Study:

To characterize the gut microbiome's bacteriological profile in PCa patients.
To investigate alterations in the gut microbiota during and after radiation therapy.
To explore correlations between microbiome changes and blood biochemical parameters.

Main Methods:

Fecal samples collected from 41 PCa patients before, during, and after radiotherapy.
Microbial identification using MALDI-TOF MS for precise species and genus-level analysis.
Assessment of blood biochemical parameters and correlation analysis with microbial data.

Main Results:

Identified 291 microbial isolates, with Escherichia, Streptococcus, and Enterococcus as dominant genera.
Observed a significant decrease in E. coli and the emergence of Citrobacter during radiotherapy.
Noted decreases in liver enzymes and increases in IL-6 levels, correlating with treatment.

Conclusions:

Radiation therapy significantly alters gut microbiota composition in PCa patients.
Treatment reduces microbial diversity and promotes opportunistic pathogen growth.
Microbiome shifts are linked to biochemical changes, suggesting potential health implications.