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Roles of long non-coding RNA HULC in human digestive system cancers.
1Three Gorges University Hospital of Traditional Chinese Medicine & Yichang Hospital of Traditional Chinese Medicine, Yichang, China.
Frontiers in Oncology
|September 5, 2025
Summary
Long non-coding RNA HULC (HULC) drives digestive system cancers like HCC, GC, PC, and CRC. This review explores HULC
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Digestive system cancers (HCC, GC, PC, CRC) present a major global health challenge.
- Tumorigenesis involves complex genetic and environmental interactions.
- Long non-coding RNAs (lncRNAs) are key regulators in cancer development and progression.
Purpose of the Study:
- To review the biological roles and molecular mechanisms of HULC in digestive system cancers.
- To summarize the clinical implications and potential of HULC as a biomarker and therapeutic target.
Main Methods:
- Literature review of recent advances in HULC research.
- Analysis of HULC's involvement in cancer initiation, metastasis, and drug resistance.
- Exploration of HULC's mechanistic actions, including the Warburg effect and EMT induction.
Main Results:
- HULC is significantly upregulated in HCC, GC, PC, and CRC.
- HULC expression correlates with advanced stage, metastasis, and poor prognosis.
- HULC promotes tumor progression by interacting with cellular components and pathways.
Conclusions:
- HULC is a critical oncogenic lncRNA in digestive system cancers.
- HULC shows potential as a diagnostic biomarker and therapeutic target for precision medicine.
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