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Published on: March 15, 2024
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Delayed hypertensive crisis after intracavernosal phenylephrine for penile plication
1Department of Anaesthesiology University of North Carolina Chapel Hill NC USA.
Anaesthesia Reports
|September 5, 2025
Summary
Intracavernosal phenylephrine injection during penile plication can cause delayed hypertensive emergencies. Careful postoperative monitoring is crucial to manage potential hemodynamic changes after this Peyronie
Area of Science:
- Urology
- Pharmacology
- Cardiovascular Medicine
Background:
- Intracavernosal phenylephrine is standard for penile plication in Peyronie's disease, aiding detumescence via vasoconstriction.
- Systemic absorption is possible, but high doses for priapism show a good safety profile with rare hemodynamic issues.
Purpose of the Study:
- To report a case of delayed hypertensive emergency after intraoperative intracavernosal phenylephrine injection during penile plication for Peyronie's disease.
- To emphasize the need for vigilant postoperative monitoring for hemodynamic instability.
Main Methods:
- A 68-year-old male patient underwent ambulatory penile plication.
- Intraoperative intracavernosal phenylephrine injection was administered.
- Postoperative monitoring was conducted.
Main Results:
- The patient experienced a hypertensive emergency 90 minutes after surgery.
- This highlights a potential delayed hemodynamic complication.
Conclusions:
- Intraoperative intracavernosal phenylephrine can lead to delayed hypertensive emergencies.
- Judicious postoperative monitoring is essential following penile plication with intracavernosal phenylephrine injection.
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