[Expression of Concern] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen1, Fang Chen2, Ting-Ting Zhang3

  • 1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China.

Insights

Concerns have been raised regarding potential data inconsistencies in a study on salt-inducible kinase 1 expression in ovarian cancer. The investigation is ongoing to ensure the scientific integrity of the published findings.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Investigated salt-inducible kinase 1 (SIK1) expression in ovarian cancer tissues.
  • SIK1 plays a role in cellular processes relevant to cancer development.

Purpose of the Study:

  • To present data on SIK1 expression levels in ovarian cancer.
  • To provide western blot analysis for SIK1 and β-actin loading controls.

Main Methods:

  • Western blot analysis was performed on ovarian cancer tissues.
  • Expression levels of SIK1 were detected.
  • β-actin was used as a loading control.

Main Results:

  • Potential similarities in β-actin loading controls for specific patients were noted.
  • Concerns were raised about the resemblance of protein bands to data from another publication.
  • An investigation into the scientific integrity of the presented data has been initiated.

Conclusions:

  • An Expression of Concern has been issued due to potential data presentation issues.
  • The journal's Editorial Office is investigating the matter further.
  • Readers are notified of potential problems pending the investigation's outcome.

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