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Related Experiment Videos

Bufotenine reconsidered.

W R McLeod, B R Sitaram

    Acta Psychiatrica Scandinavica
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Bufotenine administration caused significant, short-lived perceptual and emotional changes in a volunteer. The compound was quickly eliminated from the blood, with metabolites appearing rapidly in urine.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Human Physiology

    Background:

    • Bufotenine is a naturally occurring psychedelic compound.
    • Understanding its effects and metabolism in humans is crucial for safety and research.

    Purpose of the Study:

    • To investigate the acute effects of intravenous bufotenine in a human subject.
    • To characterize the pharmacokinetic profile of bufotenine and its metabolites.

    Main Methods:

    • Intravenous administration of bufotenine to a single, medically trained volunteer.
    • Observation of perceptual and emotional changes.
    • Blood and urine sampling for pharmacokinetic analysis.

    Main Results:

    • Profound, transient perceptual and emotional alterations were observed.

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  • Bufotenine exhibited rapid clearance from the bloodstream.
  • Metabolites of bufotenine were promptly detected in urine samples.

    • Conclusions:

    • Intravenous bufotenine induces significant but temporary psychoactive effects in humans.
    • The compound undergoes rapid metabolism and excretion.
    • Further research may explore bufotenine's neurobiological mechanisms and therapeutic potential.