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A zwitterionic dual-network hydrogel patch with anti-inflammatory properties for efficient peritoneal adhesion

Yangrui Du1, Li Ma1, Shiying Lang1

  • 1College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China. lgy3506@scu.edu.cn.

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|September 5, 2025
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A new dual-network hydrogel patch (GPSB) effectively prevents postoperative peritoneal adhesions by combining gelatin and polysulfobetaine (PSB) networks. This innovative biomaterial offers antibacterial and anti-inflammatory properties for enhanced surgical recovery.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Postoperative peritoneal adhesions are a common complication after abdominal surgery, leading to significant morbidity.
  • Current adhesion prevention strategies have limitations, necessitating the development of novel solutions.

Purpose of the Study:

  • To develop and evaluate a dual-network hydrogel patch (GPSB) for effective prevention of postoperative peritoneal adhesions.
  • To investigate the antibacterial, anti-inflammatory, and mechanical properties of the GPSB hydrogel.

Main Methods:

  • Fabrication of a dual-network hydrogel by interpenetrating gelatin and polysulfobetaine (PSB) networks.
  • Dynamic crosslinking of the gelatin network using zinc ion-polyphenol coordination.
  • In situ polymerization of the PSB network within the gelatin matrix.
  • Assessment of mechanical properties (Young's modulus, shear strength) and protein adsorption resistance.
  • Evaluation of antibacterial activity and modulation of macrophage-mediated inflammatory responses.

Main Results:

  • The GPSB hydrogel exhibited enhanced mechanical integrity with a Young's modulus of 97.7 ± 5.2 kPa and shear strength of 28.5 kPa.
  • The PSB component significantly reduced nonspecific protein adsorption (46-fold) and inflammatory cytokine secretion (approx. 70%).
  • The hydrogel demonstrated inherent antibacterial and pro-healing activities, alongside effective peritoneal adhesion prevention in preclinical models.

Conclusions:

  • The GPSB dual-network hydrogel patch is a promising multifunctional biomaterial for preventing postoperative peritoneal adhesions.
  • Its synergistic antibacterial and anti-inflammatory properties offer robust protection against surgical complications.
  • This study presents a next-generation anti-adhesion biomaterial with potential for clinical translation.