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High-dose prenalterol in beta-blockade intoxication.

K Lindvall, M Personne, A Sjögren

    Acta Medica Scandinavica
    |January 1, 1985
    PubMed
    Summary
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    A massive metoprolol overdose was treated with prenalterol, an antidote, and epinephrine. High-dose prenalterol titration proved effective in managing beta-blocker intoxication and cardiac arrest.

    Area of Science:

    • Cardiology
    • Clinical Toxicology

    Background:

    • Beta-blocker overdose is a serious medical condition.
    • Metoprolol overdose can lead to severe cardiovascular complications, including asystole.

    Observation:

    • A case of massive metoprolol (7.5 g) intoxication is presented.
    • The patient experienced mechanical asystole and required 4 hours of resuscitation.
    • Treatment involved prenalterol (420 mg initially, then 30 mg repeated doses) and intermittent epinephrine.

    Findings:

    • Prenalterol demonstrated efficacy as an antidote in this severe beta-blocker intoxication case.
    • High-dose titration of prenalterol was necessary for successful resuscitation and recovery.
    • The patient recovered within 24 hours.

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    Implications:

    • Prenalterol is a valuable therapeutic option for managing life-threatening beta-blocker overdoses.
    • Clinicians should consider aggressive titration of prenalterol in cases of severe beta-blocker toxicity.
    • This case highlights the potential for high-dose prenalterol use in critical care settings.