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Skeletal growth in uremia.

E Ritz, O Mehls, B Krempien

    Advances in Experimental Medicine and Biology
    |January 1, 1977
    PubMed
    Summary
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    Chronic renal failure in growing rats causes significant bone disease and impaired growth, particularly in terminal stages. Uremic rats show diminished weight gain, suggesting higher energy needs for growth.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Pediatric Bone Disease

    Background:

    • Chronic renal failure (CRF) in growing animals leads to bone disease.
    • CRF is associated with impaired mineralization (rickets) and elevated parathyroid hormone.
    • Growth is affected differently in preterminal versus terminal CRF.

    Purpose of the Study:

    • To investigate the impact of CRF on longitudinal growth and weight gain in Sprague Dawley rats.
    • To compare growth parameters in rats with terminal uremia versus controls at identical food intake.
    • To explore potential increased energy expenditure associated with growth in uremic conditions.

    Main Methods:

    • Induction of stable long-term chronic renal failure in Sprague Dawley rats.
    • Comparison of longitudinal growth rates between uremic and sham-operated control rats.

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  • Assessment of weight gain at identical food intake levels in terminal uremia.

    • Main Results:

    • Significant bone disease with impaired mineralization and increased parathyroid hormone activity observed in CRF rats.
    • Longitudinal growth was not diminished in preterminal renal failure.
    • Longitudinal growth and weight gain were significantly diminished in terminal renal failure compared to controls at identical food intake.

    Conclusions:

    • CRF induces substantial bone disease in growing rats.
    • Growth impairment in terminal uremia is not solely due to reduced food intake.
    • Terminal uremia may increase the energetic cost of growth.