Related Experiment Video
Updated: Sep 9, 2025

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
Published on: August 2, 2021
Effect of an AI agent trained on a large language model (LLM) as an intervention for depression and anxiety symptoms
Yuqing Zhao1,2, Wei Qian1,3, Yaru Chen1,2
1State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Background:
Young adults face emotional problems in their daily lives. Considering that youth are prevalent among mobile internet users, it would be helpful if functions that can intervene in young people's depression and anxiety can be designed based on short video apps. Large language model (LLM)-based AI conversational agents based on short video apps may play an important role in intervening in young adults' negative emotions.
Methods:
This study is a 28-day randomized controlled trial (RCT) in which 865 participants were randomly assigned to an intervention group or a waiting group, and each user was asked to engage in a total of 28 days of dialog intervention with the AI agent and complete three psychological questionnaires.
Results:
The dialog intervention significantly reduced depression in the intervention group at two weeks and significantly reduced both depression and anxiety in the intervention group at four weeks.
Conclusions:
This study found evidence that the LLM-based conversational agent could effectively alleviate the mild anxiety and depressive symptoms of young adults with negative emotions through dialog interventions when the AI companion bot is used sufficiently enough.
Registration:
Clinicaltrials.gov NCT06346496, https://clinicaltrials.gov/study/NCT06346496.
Related Concept Videos
Modeling in Therapy
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Treatment Strategies for Psychological Disorders
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Antidepressant Drugs: MAOIs and Other Agents
Social Anxiety Disorder
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Generalized Anxiety Disorder

